The role of energy cost on accuracy, sensitivity, specificity, speed and adaptation of T cell foreign and self recognition

The critical role of energy consumption in biological systems including T cell discrimination process has been investigated various ways. kinetic proofreading(KPR) recognition involving different levels dissipation influences functional outcomes such as error rates and specificity. In this work, we study quantitatively how the cost fractions, sensitivity, specificity, speed terms Mean First Passage Time(MFPT) adaption errors. These provide background to adequately understand dynamics. It is found that plays a central system aims achieve minimum fractions maximum sensitivity specificity with fastest under our scheme for which numerical values parameters are specially chosen, but condition can be broken varying data. Starting application steady state approximation(SSA) evaluation concentration each complex produced associated KPR, used quantify observables, present both analytical results detail.